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Article

Identification of SAP97 as an intracellular binding partner of TACE.

Journal of cell science - 15 May 2003

Peiretti Franck, Deprez-Beauclair Paule, Bonardo Bernadette, Aubert Helene, Juhan-Vague Irene, Nalbone Gilles

Abstract excerpt

Tumor necrosis factor alpha converting enzyme (TACE) is the metalloprotease-disintegrin responsible for the ectodomain shedding of several proteins, including tumor necrosis factor alpha. Using the yeast two-hybrid system, we identified the scaffolding protein synapse associated protein 97 (SAP97) as a binding partner of the cytoplasmic domain of TACE. By deletions and site-directed mutagenesis, we demonstrated...

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PMID: 12668732
DOI: 10.1242/jcs.00415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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