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Article

p53 gene mutation in hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates.

Japanese journal of cancer research : Gann - 1 May 1994

Fujimoto Y, Hampton L L, Snyderwine E G, Nagao M, Sugimura T, Adamson R H, Thorgeirsson S S

Abstract excerpt

2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is one of several heterocyclic amines formed during the cooking of proteinaceous foods. IQ is a potent carcinogen in rodent bioassays and causes a high incidence of hepatocellular carcinomas in nonhuman primates. We examined 20 hepatocellular carcinomas (HCCs) from nonhuman primates for mutations of the p53 gene using polymerase chain reaction-single strand...

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Identifiers

PMID: 8014109
DOI: 10.1111/j.1349-7006.1994.tb02387.x
PMCID: PMC5919498

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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