Article
p53 gene mutation in hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates.
Japanese journal of cancer research : Gann - 1 May 1994
Fujimoto Y, Hampton L L, Snyderwine E G, Nagao M, Sugimura T, Adamson R H, Thorgeirsson S S
Abstract excerpt
2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) is one of several heterocyclic amines formed during the cooking of proteinaceous foods. IQ is a potent carcinogen in rodent bioassays and causes a high incidence of hepatocellular carcinomas in nonhuman primates. We examined 20 hepatocellular carcinoma...
Topics
- Animals
- Base Sequence
- Carcinoma, Hepatocellular
- Genes, p53
- Liver Neoplasms
- Macaca fascicularis
- Molecular Sequence Data
- Mutagens
- Mutation
- Polymerase Chain Reaction
- Quinolines