Article
Virulence of selected Mycobacterium tuberculosis clinical isolates in the rabbit model of meningitis is dependent on phenolic glycolipid produced by the bacilli.
The Journal of infectious diseases - 1 Jul 2005
Tsenova Liana, Ellison Evette, Harbacheuski Ryhor, Moreira Andre L, Kurepina Natalia, Reed Michael B, Mathema Barun, Barry Clifton E, Kaplan Gilla
Abstract excerpt
Infection with Mycobacterium tuberculosis in humans results in active disease in approximately 10% of immune-competent individuals, with the most-severe clinical manifestations observed when the bacilli infect the central nervous system (CNS). Here, we use a rabbit model of tuberculous meningitis to evaluate the severity of disease caused by the M. tuberculosis clinical isolates CDC1551, a highly immunogenic...
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