Article

Protein kinase F regulates the virulence of <i>Mycobacterium tuberculosis</i>

2025-12-05

Abstract excerpt

The serine/threonine protein kinase F (PknF) of Mycobacterium tuberculosis (Mtb) has poorly defined targets and functions but is involved in limiting NLRP3 inflammasome activation in murine macrophages and dendritic cells in vitro . The importance of PknF for the virulence of Mtb in vivo is not known. Here, we demonstrate that the Mtb CDC1551 deletion mutant of pknF ( Δ pknF ) expresses significantly increase...

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Literature Corpus work: afcca1ef-fa23-53ba-a368-6a8612065473
DOI: 10.64898/2025.12.04.692467

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