Article
Mycobacterium tuberculosis lineage influences innate immune response and virulence and is associated with distinct cell envelope lipid profiles.
PloS one - 1 Jan 2011
Krishnan Nitya, Malaga Wladimir, Constant Patricia, Caws Maxine, Tran Thi Hoang Chau, Salmons Jenifer, Nguyen Thi Ngoc Lan, Nguyen Duc Bang, Daffé Mamadou, Young Douglas B, Robertson Brian D, Guilhot Christophe, Thwaites Guy E
Abstract excerpt
The six major genetic lineages of Mycobacterium tuberculosis are strongly associated with specific geographical regions, but their relevance to bacterial virulence and the clinical consequences of infection are unclear. Previously, we found that in Vietnam, East Asian/Beijing and Indo-Oceanic strains were significantly more likely to cause disseminated tuberculosis with meningitis than those from the...
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