Article
Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012.
The Journal of infectious diseases - 1 Jul 2005
Flys Tamara, Nissley Dwight V, Claassen Cassidy W, Jones Dana, Shi Chanjuan, Guay Laura A, Musoke Philippa, Mmiro Francis, Strathern Jeffrey N, Jackson J Brooks, Eshleman James R, Eshleman Susan H
Abstract excerpt
BACKGROUND: The HIV Network for Prevention Trials (HIVNET) 012 trial showed that NVP resistance (NVPR) emerged in some women and children after the administration of single-dose nevirapine (SD-NVP). We tested whether K103N-containing human immunodeficiency virus (HIV)-1 variants persisted in women and infants 1 year or more after the administration of SD-NVP. METHODS: We analyzed samples from 9 women and 5...
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