Article
Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D.
Journal of acquired immune deficiency syndromes (1999) - 15 Aug 2006
Flys Tamara S, Chen Shu, Jones Dana C, Hoover Donald R, Church Jessica D, Fiscus Susan A, Mwatha Anthony, Guay Laura A, Mmiro Francis, Musoke Philippa, Kumwenda Newton, Taha Taha E, Jackson J Brooks, Eshleman Susan H
Abstract excerpt
INTRODUCTION: We used a sensitive point mutation assay, LigAmp, to detect and quantify K103N-containing variants in African women who received single-dose nevirapine (NVP) to prevent mother-to-child HIV-1 transmission. METHODS: Plasma for testing was collected 6 to 8 weeks postpartum from 301 women (144 subtype A, 63 subtype C, and 94 subtype D). RESULTS: The portion of women with 0.5% or more K103N-containing...
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