Article
Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin.
Chemotherapy - 1 Jan 2011
Sanfilippo Christine M, Hesje Christine K, Haas Wolfgang, Morris Timothy W
Abstract excerpt
BACKGROUND: The impact of mutations in DNA gyrase and topoisomerase IV on minimum inhibitory concentrations (MICs) was investigated to better understand why besifloxacin has a higher potency against Staphylococcus aureus when compared to other fluoroquinolones, which was especially pronounced against ciprofloxacin-resistant isolates. METHODS: MICs were determined for 52 clinical isolates against besifloxacin,...
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