Molecular characterization of quinolone resistance-determining regions and their correlation with serotypes and genotypes among Streptococcus pneumoniae isolates in Japan.

doi:10.1007/s10096-009-0832-3

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Article

Molecular characterization of quinolone resistance-determining regions and their correlation with serotypes and genotypes among Streptococcus pneumoniae isolates in Japan.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Feb 2010

Osawa M, Ito Y, Ishida T, Imai S, Ichiyama S, Mishima M

Abstract excerpt

We established the distribution of amino acid alterations in quinolone resistance-determining regions (QRDRs) of Streptococcus pneumoniae isolates in Japan and described the correlation of these alterations with serotypes determined by multilocus sequencing typing. Among 141 S. pneumoniae isolates, five levofloxacin-resistant isolates harbored mutations in both gyrA and parC and/or parE and were clonally...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents
DNA Gyrase
DNA Mutational Analysis
DNA Topoisomerase IV
DNA, Bacterial
Drug Resistance, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Bacterial

Genotype

Humans

Japan

Microbial Sensitivity Tests

Middle Aged

Mutation, Missense

Pneumococcal Infections

Source

Open in PubMed

Identifiers

PMID: 19936985
DOI: 10.1007/s10096-009-0832-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19936985-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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