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Article

Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 1996

Prabhu N S, Blagosklonny M V, Zeng Y X, Wu G S, Waldman T, El-Deiry W S

Abstract excerpt

p53 tumor suppression is deficient in the majority of human cancers. Efforts to understand this pathway have identified cyclin-dependent kinase (CDK) inhibitors and suggested a potential for their replacement in human cancer. In the present studies, expression of a C-terminal deletion mutant of the human p21(WAF1/CIP1) CDK inhibitor completely suppressed the growth of colon cancer cells, whereas full-length p21...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9816291

Genes

CDK2
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.PMID 9816291Read ↗

C-terminal deletion mutant p21(WAF1/CIP1) enhances E2F-1-mediated apoptosis in colon adenocarcinoma cells.Semantic proximity Read ↗

The Cyclin-Dependent Kinase Inhibitor p21CDKN1A as a Target of Anti-Cancer DrugsSemantic proximity Read ↗

p21 contains independent binding sites for cyclin and cdk2: both sites are required to inhibit cdk2 kinase activity.Semantic proximity Read ↗

RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of AktSemantic proximity Read ↗

COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis.Semantic proximity Read ↗

Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57 KIP2 requires binding to proliferating cell nuclear antigenSemantic proximity Read ↗

Effects of p21cip1/waf1 overexpression on growth, apoptosis and differentiation in human colon carcinoma cells.Semantic proximity Read ↗

Effects of ectopic overexpression of p21(WAF1/CIP1) on aneuploidy and the malignant phenotype of human brain tumor cells.Semantic proximity Read ↗

p21WAF1/CIP1 expression in colorectal carcinoma correlates with advanced disease stage and p53 mutations.Semantic proximity Read ↗

Clinical utility of recombinant adenoviral human p53 gene therapy: current perspectivesSemantic proximity Read ↗

Two variants of the CIP1/WAF1 gene occur together and are associated with human cancer.Semantic proximity Read ↗

Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells.Semantic proximity Read ↗

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