Article
Suppression of cancer cell growth by adenovirus expressing p21(WAF1/CIP1) deficient in PCNA interaction.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 1996
Prabhu N S, Blagosklonny M V, Zeng Y X, Wu G S, Waldman T, El-Deiry W S
Abstract excerpt
p53 tumor suppression is deficient in the majority of human cancers. Efforts to understand this pathway have identified cyclin-dependent kinase (CDK) inhibitors and suggested a potential for their replacement in human cancer. In the present studies, expression of a C-terminal deletion mutant of t...
Topics
- Adenoviridae
- Apoptosis
- CDC2-CDC28 Kinases
- Cell Division
- Colonic Neoplasms
- Cyclin-Dependent Kinase 2
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- Humans
- Mutation
- Oncogene Proteins, Viral
- Proliferating Cell Nuclear Antigen
- Protein Serine-Threonine Kinases
- Repressor Proteins
- Transfection
- Tumor Cells, Cultured