Article
Association of CTLA4 polymorphism with regulatory T cell frequency.
European journal of immunology - 1 Jul 2005
Atabani Sowsan F, Thio Chloe L, Divanovic Senad, Trompette Aurelien, Belkaid Yasmine, Thomas David L, Karp Christopher L
Abstract excerpt
A common single nucleotide polymorphism in CTLA4 has been linked with susceptibility and outcome in autoimmune and infectious diseases, respectively. Here, we show that this polymorphism is associated with the frequency of CD4(+)CD25(+) regulatory T cells in healthy human volunteers. We further show that, on a per cell basis, such regulatory T cells appear to be functionally indistinguishable across CTLA4...
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