Sex-dependent complex association of TPH2 with multiple dimensions of ADHD.

doi:10.1016/j.pnpbp.2021.110296

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Article

Sex-dependent complex association of TPH2 with multiple dimensions of ADHD.

Progress in neuro-psychopharmacology & biological psychiatry - 30 Aug 2021

Fageera Weam, Sengupta Sarojini M, Fortier Marie-Ève, Grizenko Natalie, Babienco Svetlana, Labbe Aurelie, Joober Ridha

Abstract excerpt

BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is a key enzyme in the biosynthesis of serotonin in the brain. This study aims to investigate the role of a functional variant in TPH2 (rs17110747) in the pathophysiology of ADHD. This variant has been implicated in mood disorders in recent meta-analysis. This study uses a comprehensive approach that combines association testing and pharmaco-dynamic evaluation of...

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PMID: 33677046
DOI: 10.1016/j.pnpbp.2021.110296

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