Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations.

doi:10.1002/ajmg.b.31067

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Article

Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2010

Johansson Stefan, Halmøy Anne, Mavroconstanti Thegna, Jacobsen Kaya K, Landaas Elisabeth T, Reif Andreas, Jacob Christian, Boreatti-Hümmer Andrea, Kreiker Susanne, Lesch Klaus-Peter, Kan Cornelis C, Kooij J J Sandra, Kiemeney Lambertus A, Buitelaar Jan K, Franke Barbara, Ribasés Marta, Bosch Rosa, Bayés Mònica, Casas Miguel, Ramos-Quiroga Josep Antoni, Cormand Bru, Knappskog Per, Haavik Jan

Abstract excerpt

The tryptophan hydroxylase 1 and 2 (TPH1 and TPH2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. Genetic variants in both genes have been implicated in several psychiatric disorders. For attention-deficit/hyperactivity disorder (ADHD) in children, the results are conflicting, and little is known about their role in adult ADHD patients. We therefore first genotype-tagged all common variants...

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Identifiers

PMID: 20213726
DOI: 10.1002/ajmg.b.31067

Genes

TPH1
TPH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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