Article
Functional analyses of mouse ASK, an activation subunit for Cdc7 kinase, using conditional ASK knockout ES cells.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jun 2005
Yamashita Nobuyuki, Kim Jung-Min, Koiwai Osamu, Arai Ken-ichi, Masai Hisao
Abstract excerpt
ASK (activator of S phase kinase) is an activation subunit for mammalian Cdc7 kinase. We have generated mutant ES cell lines in which ASK can be conditionally inactivated. Upon loss of the ASK genes, the mutant ES cells rapidly cease cell growth. In keeping with its expected roles in activation of the essential S phase kinase, DNA synthesis is arrested and significant cell death is eventually induced in...
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