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Article

Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in vivo.

Molecular and cellular biology - 1 May 2007

Zhan Jun, Easton John B, Huang Shile, Mishra Ashutosh, Xiao Limin, Lacy Eilyn R, Kriwacki Richard W, Houghton Peter J

Abstract excerpt

The cyclin-dependent kinase inhibitor p21(Cip1) regulates multiple cellular functions and protects cells from genotoxic and other cellular stresses. Activation of apoptosis signal-regulating kinase 1 (ASK1) induced by inhibition of mTOR signaling leads to sustained phospho-c-Jun that is suppressed in cells with functional p53 or by forced expression of p21(Cip1). Here we show that small deletions of p21(Cip1)...

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Identifiers

PMID: 17325029
DOI: 10.1128/MCB.00086-06
PMCID: PMC1899956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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