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Article

Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP.

G3 (Bethesda, Md.) - 3 Apr 2017

Wang Ying, Naturale Victor F, Adler Paul N

Abstract excerpt

The Planar cell Polarity Effector (PPE) genes inturned, fuzzy, and fritz are downstream components in the frizzled/starry night signaling pathway, and their function is instructed by upstream Planar Cell Polarity (PCP) core genes such as frizzled and dishevelled PPE proteins accumulate asymmetrically in wing cells and function in a protein complex mediated by direct interactions between In and Frtz and In and Fy....

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Identifiers

PMID: 28258110
DOI: 10.1534/g3.116.038695
PMCID: PMC5386880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP.PMID 28258110Read ↗

Inturned localizes to the proximal side of wing cells under the instruction of upstream planar polarity proteins.Semantic proximity Read ↗

A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila Wings.Semantic proximity Read ↗

Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling.Semantic proximity Read ↗

The WD40 repeat protein fritz links cytoskeletal planar polarity to frizzled subcellular localization in the Drosophila epidermis.Semantic proximity Read ↗

Novel regulators of planar cell polarity: a genetic analysis in Drosophila.Semantic proximity Read ↗

The frizzled/stan pathway and planar cell polarity in the Drosophila wing.Semantic proximity Read ↗

Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling.Semantic proximity Read ↗

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding.Semantic proximity Read ↗

The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family.Semantic proximity Read ↗

Two separate molecular systems, Dachsous/Fat and Starry night/Frizzled, act independently to confer planar cell polarity.Semantic proximity Read ↗

Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.Semantic proximity Read ↗

The tumor-suppressor and cell adhesion molecule Fat controls planar polarity via physical interactions with Atrophin, a transcriptional co-repressor.Semantic proximity Read ↗

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