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Article

Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development.

Developmental cell - 1 Jun 2005

Ossipova Olga, Dhawan Sangeeta, Sokol Sergei, Green Jeremy B A

Abstract excerpt

The kinase PAR-1 plays conserved roles in cell polarity. PAR-1 has also been implicated in axis establishment in C. elegans and Drosophila and in Wnt signaling, but its role in vertebrate development is unclear. Here we report that PAR-1 has two distinct and essential roles in axial development in Xenopus mediated by different PAR-1 isoforms. Depletion of PAR-1A or PAR-1BX causes dorsoanterior deficits, reduced...

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Identifiers

PMID: 15935773
DOI: 10.1016/j.devcel.2005.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development.PMID 15935773Read ↗

A Drosophila melanogaster homologue of Caenorhabditis elegans par-1 acts at an early step in embryonic-axis formation.Semantic proximity Read ↗

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry.Semantic proximity Read ↗

PAR1b promotes cell-cell adhesion and inhibits dishevelled-mediated transformation of Madin-Darby canine kidney cells.Semantic proximity Read ↗

The C. elegans homolog of Drosophila Lethal giant larvae functions redundantly with PAR-2 to maintain polarity in the early embryo.Semantic proximity Read ↗

PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryos.Semantic proximity Read ↗

MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryo.Semantic proximity Read ↗

par-6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of PAR-3.Semantic proximity Read ↗

The Caenorhabditis elegans par-5 gene encodes a 14-3-3 protein required for cellular asymmetry in the early embryo.Semantic proximity Read ↗

Membrane targeting of Bazooka/PAR-3 is mediated by direct binding to phosphoinositide lipids.Semantic proximity Read ↗

Anterior PAR proteins function during cytokinesis and maintain DYN-1 at the cleavage furrow in Caenorhabditis elegans.Semantic proximity Read ↗

Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia.Semantic proximity Read ↗

A genome-wide RNAi screen for enhancers of par mutants reveals new contributors to early embryonic polarity in Caenorhabditis elegans.Semantic proximity Read ↗

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