Article
No association between tumor necrosis factor-alpha production and gene polymorphisms among inbred rat strains.
Transplant immunology - 1 Jun 2005
Warlé Michiel C, van der Laan Luc J W, Kusters Johannes G, Pot Raymond G J, Hop Wim C J, Segeren Katja C A, Ijzermans Jan N M, Metselaar Herold J, Tilanus Hugo W
Abstract excerpt
Differences in spontaneous allograft acceptance after liver transplantation among inbred rat strains might be explained by variation in the local production of TNF-alpha as a potent mediator of the inflammatory response. In this study, we hypothesize that nucleotide differences in the rat Tnf gene influence TNF-alpha protein expression. As such, polymorphisms in the Tnf gene may also provide a possible...
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