Article
Comparative expression of TNF-alpha alleles from normal and autoimmune-prone MHC haplotypes.
Journal of inflammation - 1 Jan 1995
Bazzoni F, Beutler B
Abstract excerpt
The tumor necrosis factor-alpha (TNF-alpha, or TNF) genes of NOD mice and NZW mice are reportedly underexpressed relative to the TNF genes of control mice in lipopolysaccharide (LPS)-induced peritoneal macrophages. These findings, as well as the well-known major histocompatibility complex (MHC) linkage of the TNF genes, have prompted speculation that mutations affecting expression of the TNF-alpha loci might...
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