Article

Activity and Dynamics of p110α are not Differentially Modulated by Regulatory Subunit Isoforms

2025-10-17

Abstract excerpt

Class IA phosophoinositide kinases (PI3Ks) are master regulators of growth, metabolism, and immunity. The class IA PI3Ks are a heterodimer composed of a p110 catalytic subunit and one of five possible regulatory subunits (p85α, p85β, p55γ, p55α, p50α). The regulatory subunit plays critical roles in stability, inhibition, and activation of the p110 catalytic subunit. The p110α catalytic subunit frequently contains...

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Identifiers and source

Literature Corpus work: a9c51866-bb61-563a-8b4e-426560144609
DOI: 10.1101/2025.10.16.682970

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