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Article

Pro-oxidant action of diphenyl diselenide in the yeast Saccharomyces cerevisiae exposed to ROS-generating conditions.

Life sciences - 23 Sept 2005

Moreira Rosa Renato, de Oliveira Ramatis Birnfeld, Saffi Jenifer, Braga Antônio Luís, Roesler Rafael, Dal-Pizzol Felipe, Fonseca Moreira José Cláudio, Brendel Martin, Pêgas Henriques João Antonio

Abstract excerpt

Organoselenium compounds have a potential thiol peroxidase-like activity. Diphenyl diselenide (DPDS) is an electrophilic reagent used in the synthesis of a variety of pharmacologically active organic selenium compounds. Using TRAP assay of chemiluminescense we have shown that diphenyl diselenide clearly possesses a pro-oxidant property. For an investigation on the mechanisms of this property, we used mutant...

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PMID: 15932762
DOI: 10.1016/j.lfs.2005.01.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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