Article
Menadione stress in Saccharomyces cerevisiae strains deficient in the glutathione transferases.
Biochimica et biophysica acta - 1 Feb 2007
Castro F A V, Herdeiro R S, Panek A D, Eleutherio E C A, Pereira M D
Abstract excerpt
Using S. cerevisiae as a eukaryotic cell model we have analyzed the involvement of both glutathione transferase isoforms, Gtt1 and Gtt2, in constitutive resistance and adaptive response to menadione, a quinone which can exert its toxicity as redox cycling and/or electrophiles. The detoxification properties, of these enzymes, have also been analyzed by the appearance of S-conjugates in the media. Direct exposure...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
