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Article

Dosing algorithm for warfarin using CYP2C9 and VKORC1 genotyping from a multi-ethnic population: comparison with other equations.

Pharmacogenomics - 1 Feb 2008

Wu Alan H B, Wang Ping, Smith Andrew, Haller Christine, Drake Katherine, Linder Mark, Valdes Roland

Abstract excerpt

OBJECTIVES: Polymorphism in the genes for cytochrome (CYP)2C9 and the vitamin K epoxide reductase complex subunit 1 (VKORC1) affect the pharmacokinetics and pharmacodynamics of warfarin. We developed and validated a warfarin-dosing algorithm for a multi-ethnic population that predicts the best dose for stable anticoagulation, and compared its performance against other regression equations. METHODS: We determined...

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Source

Identifiers

PMID: 18370846
DOI: 10.2217/14622416.9.2.169

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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