Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel.

doi:10.1016/0896-6273(93)90150-p

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Article

Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel.

Neuron - 1 Sept 1993

Root M J, MacKinnon R

Abstract excerpt

Divalent cation blockade of cGMP-gated channels in photoreceptor cells ensures the low open channel noise required for a highly sensitive visual transduction process. This study identifies a divalent cation-binding site in the pore of a retinal cGMP-gated channel expressed in Xenopus oocytes. Sub...

Topics

Animals
Base Sequence
Binding Sites
Cations, Divalent
Cyclic GMP
Electrophysiology
Ion Channels
Molecular Sequence Data
Mutation
Oocytes
Xenopus

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