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Article

Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel.

Neuron - 1 Sept 1993

Root M J, MacKinnon R

Abstract excerpt

Divalent cation blockade of cGMP-gated channels in photoreceptor cells ensures the low open channel noise required for a highly sensitive visual transduction process. This study identifies a divalent cation-binding site in the pore of a retinal cGMP-gated channel expressed in Xenopus oocytes. Substitution of a specific glutamate residue by a neutral amino acid renders the channel insensitive to external Mg2+ and...

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PMID: 7691102
DOI: 10.1016/0896-6273(93)90150-p

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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