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Article

Mutation of a single residue in the S2-S3 loop of CNG channels alters the gating properties and sensitivity to inhibitors.

The Journal of general physiology - 1 Dec 2000

Crary J I, Dean D M, Maroof F, Zimmerman A L

Abstract excerpt

We previously found that native cyclic nucleotide-gated (CNG) cation channels from amphibian rod cells are directly and reversibly inhibited by analogues of diacylglycerol (DAG), but little is known about the mechanism of this inhibition. We recently determined that, at saturating cGMP concentrations, DAG completely inhibits cloned bovine rod (Brod) CNG channels while only partially inhibiting cloned rat...

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Identifiers

PMID: 11099346
DOI: 10.1085/jgp.116.6.769
PMCID: PMC2231820

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Source receipt: pubmed, retrieved 7 Sept 2026.

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