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Article

A pore-lining glutamic acid in the rat olfactory cyclic nucleotide-gated channel controls external spermine block.

Neuroscience letters - 22 Dec 2000

Nevin S T, Haddrill J L, Lynch J W

Abstract excerpt

Spermine is a potent, voltage-dependent blocker of the olfactory cyclic nucleotide-gated channel from both the intracellular and extracellular sides. However, its sites of action are unknown. This study investigated the external spermine binding site in the rat CNCalpha3 subunit. Neutralization of a glutamic acid residue (E342Q) in the P-loop region eliminated voltage-dependence of block by externally applied...

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Source

Identifiers

PMID: 11109006
DOI: 10.1016/s0304-3940(00)01650-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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