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Article

Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure

1 Jun 2005

Abstract excerpt

BACKGROUND: Abnormalities of intracellular calcium handling are widely recognized as a common hallmark of heart failure in animal models and humans. Modifying the interaction of phospholamban (PLB) with the sarcoplasmic reticulum ATPase (SERCA) by PLB mutants improves cardiac function but may also lead to heart failure. In this study we describe the in vivo effects of a new approach to modify the PLB-SERCA...

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Share to Cardiac electrophysiology and arrhythmias
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Identifiers

PMID: 15927173
DOI: 10.1016/j.cardiores.2005.04.029

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