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Article

Viral expression of a SERCA2a-activating PLB mutant improves calcium cycling and synchronicity in dilated cardiomyopathic hiPSC-CMs.

Journal of molecular and cellular cardiology - 1 Jan 2020

Stroik Daniel R, Ceholski Delaine K, Bidwell Philip A, Mleczko Justyna, Thanel Paul F, Kamdar Forum, Autry Joseph M, Cornea Razvan L, Thomas David D

Abstract excerpt

There is increasing momentum toward the development of gene therapy for heart failure (HF) that is defined by impaired calcium (Ca2+) transport and reduced contractility. We have used FRET (fluorescence resonance energy transfer) between fluorescently-tagged SERCA2a (the cardiac Ca2+ pump) and PLB (phospholamban, ventricular peptide inhibitor of SERCA) to test directly the effectiveness of...

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Identifiers

PMID: 31751570
DOI: 10.1016/j.yjmcc.2019.11.147
PMCID: PMC7035975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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