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Article

Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure.

Cardiovascular research - 1 Nov 2002

Schmidt Albrecht G, Zhai Jing, Carr Andrew N, Gerst Mike J, Lorenz John N, Pollesello Piero, Annila Arto, Hoit Brian D, Kranias Evangelia G

Abstract excerpt

OBJECTIVE: The role of sarcoplasmic reticulum (SR) in the onset and progression of heart failure is controversial. We tested the hypothesis that impairment of SR Ca2+ sequestration may be a primary cause for progressive left ventricular (LV) dysfunction and the phospholamban hinge domain may be critical in this process. METHODS: A phospholamban hinge domain mutant (PLB/N27A) was introduced in the cardiac...

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Identifiers

PMID: 12393095
DOI: 10.1016/s0008-6363(02)00541-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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