Article
Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
30 Aug 2021
Abstract excerpt
Abstract Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. Restoring the Ca2+ regulating machinery is an attractive therapeutic strategy supported by genetic and pharmacological proof of concept studies. Here, we study antisense...
Topics
Join the communities discussing this publication.