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Article

Molecular targets in heart failure gene therapy: current controversies and translational perspectives

1 Apr 2012

Abstract excerpt

Use of gene therapy for heart failure is gaining momentum as a result of the recent successful completion of phase II of the Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID) trial, which showed clinical safety and efficacy of an adeno-associated viral vector expressing sarco-endoplasmic reticulum calcium ATPase (SERCA2a). Resorting to gene therapy allows the...

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PMID: 22548568
DOI: 10.1111/j.1749-6632.2012.06520.x

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