Article
Mutation spectra induced by alpha-acetoxytamoxifen-DNA adducts in human DNA repair proficient and deficient (xeroderma pigmentosum complementation group A) cells.
Biochemistry - 7 Jun 2005
McLuckie Keith I E, Crookston Robert J R, Gaskell Margaret, Farmer Peter B, Routledge Michael N, Martin Elizabeth A, Brown Karen
Abstract excerpt
Tamoxifen, a breast cancer drug, has recently been approved for the chemoprevention of this disease. However, tamoxifen causes hepatic carcinomas in rats through a genotoxic mechanism and increases the risk of endometrial tumors in women. DNA adducts have been detected at low levels in human endometrium, and there is much interest in determining whether DNA damage plays a role in tamoxifen-induced endometrial...
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