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Mutagenic events induced by 4-hydroxyequilin in supF shuttle vector plasmid propagated in human cells.

Carcinogenesis - 1 May 2003

Yasui Manabu, Matsui Saburo, Laxmi Y R Santosh, Suzuki Naomi, Kim Sung Yeon, Shibutani Shinya, Matsuda Tomonari

Abstract excerpt

Increased incidence of breast, ovarian and endometrial cancers are observed in women receiving estrogen replacement therapy (ERT). Equilin and equilenin are the major components of the widely prescribed drug used for ERT. These equine estrogens are metabolized primarily to 4-hydroxyequilin (4-OHEQ) and 4-hydroxyequilenin, respectively, which are autoxidized to react with DNA, resulting in the various DNA damages....

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Identifiers

PMID: 12771036
DOI: 10.1093/carcin/bgg029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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