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Article

Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen.

Cancer research - 15 Jul 1994

Vancutsem P M, Lazarus P, Williams G M

Abstract excerpt

Tamoxifen (TAM) is a triphenylethylene antiestrogen used for the treatment, and in clinical trials for the prevention, of breast cancer in women. In rats, TAM is a strong liver carcinogen which induces the formation of liver DNA adducts. The DNA of 24 hepatocarcinomas (HCCs) collected at necropsy from individual female Sprague-Dawley rats that were given 22.6 mg/kg TAM daily for 12 months was studied for the...

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PMID: 8033108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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