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Article

Frequent and specific mutations of the rat p53 gene in hepatocarcinomas induced by tamoxifen.

Cancer research - 15 Jul 1994

Vancutsem P M, Lazarus P, Williams G M

Abstract excerpt

Tamoxifen (TAM) is a triphenylethylene antiestrogen used for the treatment, and in clinical trials for the prevention, of breast cancer in women. In rats, TAM is a strong liver carcinogen which induces the formation of liver DNA adducts. The DNA of 24 hepatocarcinomas (HCCs) collected at necropsy from individual female Sprague-Dawley rats that were given 22.6 mg/kg TAM daily for 12 months was studied for the...

Topics

Animals
Base Sequence
Female
Genes, p53
Liver Neoplasms, Experimental
Molecular Sequence Data
Mutation
Rats
Rats, Sprague-Dawley
Tamoxifen

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8033108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8033108-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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