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Article

PIK3CA Mutations: Are They a Relevant Target in Adult Diffuse Gliomas?

30 May 2025

Abstract excerpt

Gliomas are the most common and lethal malignant primary brain tumors in adults, associated with the highest number of years of potential life lost. The latest WHO classification for central nervous system tumors highlighted the need for new biomarkers of diagnosis, prognosis, and response to therapy. The PI3K/Akt signaling pathway is clearly implicated in tumorigenesis, being one of the most frequently altered...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40508087
DOI: 10.3390/ijms26115276

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