Article
Lack of association between antioxidant gene polymorphisms and progressive massive fibrosis in coal miners.
Thorax - 1 Jun 2005
Yucesoy B, Johnson V J, Kashon M L, Fluharty K, Vallyathan V, Luster M I
Abstract excerpt
BACKGROUND: Oxidative stress plays a major role in the pathogenesis of interstitial lung diseases. The antioxidant enzymes glutathione S-transferases (GST) and manganese superoxide dismutase (MnSOD) are important components of lung defence against oxidative stress, and polymorphisms in the genes which regulate their expression may represent important disease modifiers. METHODS: A matched case-control study was...
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