Article
Lack of association between glutathione S-transferase P1 polymorphism and COPD in Koreans.
Lung - 1 Jan 2002
Yim J J, Yoo C G, Lee C-T, Kim Y W, Han S K, Shim Y S
Abstract excerpt
The fact that only 10-20% of chronic heavy cigarette smokers develop symptomatic COPD and correlations of pulmonary function among twins and families suggests the presence of genetic susceptibility in the development of COPD. Genetic susceptibility to COPD might depend on the variations in enzyme activities that detoxify cigarette smoke products, such as microsomal epoxide hydrolase (mEPHX) and glutathione-S...
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