Article
Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23.
Brain : a journal of neurology - 1 Sept 2015
Smeets Cleo J L M, Jezierska Justyna, Watanabe Hiroyuki, Duarri Anna, Fokkens Michiel R, Meijer Michel, Zhou Qin, Yakovleva Tania, Boddeke Erik, den Dunnen Wilfred, van Deursen Jan, Bakalkin Georgy, Kampinga Harm H, van de Sluis Bart, Verbeek Dineke S
Abstract excerpt
Spinocerebellar ataxia type 23 is caused by mutations in PDYN, which encodes the opioid neuropeptide precursor protein, prodynorphin. Prodynorphin is processed into the opioid peptides, α-neoendorphin, and dynorphins A and B, that normally exhibit opioid-receptor mediated actions in pain signalling and addiction. Dynorphin A is likely a mutational hotspot for spinocerebellar ataxia type 23 mutations, and in vitro...
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