Article
Enlarged cholinergic forebrain neurons and improved spatial learning in p75 knockout mice.
The European journal of neuroscience - 1 Mar 2000
Greferath U, Bennie A, Kourakis A, Bartlett P F, Murphy M, Barrett G L
Abstract excerpt
The p75 low affinity neurotrophin receptor (p75) can induce apoptosis in various neuronal and glial cell types. Because p75 is expressed in the cholinergic neurons of the basal forebrain, p75 knockout mice may be expected to show an increased number of neurons in this region. Previous studies, however, have produced conflicting results, suggesting that genetic background and choice of control mice are critical....
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