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Article

Mechanisms and fitness costs of tigecycline resistance in Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Dec 2013

Linkevicius Marius, Sandegren Linus, Andersson Dan I

Abstract excerpt

OBJECTIVES: To stepwise select tigecycline-resistant Escherichia coli mutants in vitro, determine the mutation rates, identify the resistance mechanisms, determine the resistance level and cross-resistance to other antibiotic classes, evaluate the fitness costs of tigecycline resistance mechanisms and investigate if the same in vitro-identified target genes were mutated in clinical isolates. METHODS: Spontaneous...

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PMID: 23843301
DOI: 10.1093/jac/dkt263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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