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Article

Mechanisms and fitness costs of tigecycline resistance in Escherichia coli.

The Journal of antimicrobial chemotherapy - 1 Dec 2013

Linkevicius Marius, Sandegren Linus, Andersson Dan I

Abstract excerpt

OBJECTIVES: To stepwise select tigecycline-resistant Escherichia coli mutants in vitro, determine the mutation rates, identify the resistance mechanisms, determine the resistance level and cross-resistance to other antibiotic classes, evaluate the fitness costs of tigecycline resistance mechanisms and investigate if the same in vitro-identified target genes were mutated in clinical isolates. METHODS: Spontaneous...

Topics

Anti-Bacterial Agents
DNA Mutational Analysis
DNA, Bacterial
Drug Resistance, Bacterial
Energy Metabolism
Escherichia coli
Humans
Microbial Sensitivity Tests
Minocycline
Mutation
Mutation Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Selection, Genetic

Sequence Analysis, DNA

Serial Passage

Tigecycline

Source

Identifiers

PMID: 23843301
DOI: 10.1093/jac/dkt263

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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