Article
A multidrug-resistant ovarian carcinoma cell line with a malignant suppressed phenotype is a CD44 gene expression defective mutant.
Cancer genetics and cytogenetics - 1 May 1992
Teyssier J R, Couillin P, Bénard J, Ravisse N, Ulrich E, Cornillet P
Abstract excerpt
A multidrug-resistant cell subline (OV1/VCR) derived from an ovarian adenocarcinoma cell line (OV1/P) was characterized by a typical suppressed malignant phenotype and by a unique karyotypic change: del(11)(p13). In an attempt to discern some genetic alteration of 11p genes that may be relevant to the phenotypic shift, cells were analyzed with DNA probes mapped in the deleted region and with monoclonal antibodies...
Topics
- Blotting, Northern
- Blotting, Southern
- Chromosome Deletion
- Chromosomes, Human, Pair 11
- Drug Resistance
- Female
- Gene Expression
- Humans
- Ovarian Neoplasms
- Phenotype
- Receptors, Lymphocyte Homing