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Article

The dynamic envelope of a fusion class II virus. E3 domain of glycoprotein E2 precursor in Semliki Forest virus provides a unique contact with the fusion protein E1.

The Journal of biological chemistry - 26 Sept 2008

Wu Shang-Rung, Haag Lars, Sjöberg Mathilda, Garoff Henrik, Hammar Lena

Abstract excerpt

In alphaviruses, here represented by Semliki Forest virus, infection requires an acid-responsive spike configuration to facilitate membrane fusion. The creation of this relies on the chaperone function of glycoprotein E2 precursor (p62) and its maturation cleavage into the small external E3 and the membrane-anchored E2 glycoproteins. To reveal how the E3 domain of p62 exerts its control of spike functions, we...

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Identifiers

PMID: 18596032
DOI: 10.1074/jbc.M801470200
PMCID: PMC3258923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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