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Article

A conserved histidine in the ij loop of the Semliki Forest virus E1 protein plays an important role in membrane fusion.

Journal of virology - 1 Dec 2004

Chanel-Vos Chantal, Kielian Margaret

Abstract excerpt

The enveloped alphavirus Semliki Forest virus (SFV) infects cells via a low pH-triggered membrane fusion reaction mediated by the E1 protein. E1 is a class II fusion protein that contains the hydrophobic fusion peptide loop and converts to a stable homotrimer during the fusion reaction. Intriguingly, the fusion loop is closely associated with a loop connecting the i and j beta-strands. This ij loop plays a role...

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Source

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Identifiers

PMID: 15564465
DOI: 10.1128/JVI.78.24.13543-13552.2004
PMCID: PMC533937

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Source receipt: pubmed, retrieved 7 Sept 2026.

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A conserved histidine in the ij loop of the Semliki Forest virus E1 protein plays an important role in membrane fusion.PMID 15564465Read ↗

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