Article
Association of interleukin-1 receptor-associated kinase M (IRAK-M) and inflammatory bowel diseases.
Scandinavian journal of gastroenterology - 1 Jul 2007
Weersma Rinse K, Oostenbrug Liekele E, Nolte Ilja M, Van Der Steege Gerrit, Oosterom Elvira, Van Dullemen Hendrik M, Kleibeuker Jan H, Dijkstra Gerard
Abstract excerpt
OBJECTIVE: Inflammatory bowel diseases (IBD) have a complex genetic background. The interleukin receptor associated kinase-M (IRAK-M) is a NF-kappaB-mediated, negative regulator of Toll-like receptor (TLR) signaling. A functional mutation in a negative regulator might induce impaired endotoxin tolerance and increased inflammatory responses. IRAK-M is situated on chromosome 12q14, a susceptibility locus for IBD,...
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