Article
Analysis of p53 tumor suppressor gene, H-ras protooncogene and proliferating cell nuclear antigen (PCNA) in squamous cell carcinomas of HRA/Skh mice following exposure to 8-methoxypsoralen (8-MOP) and UVA radiation (PUVA therapy).
Toxicologic pathology - 1 Jan 2005
Lambertini Luca, Surin Kezia, Ton Thai-Vu T, Clayton Natasha, Dunnick June K, Kim Yongbaek, Hong Hue-Hua L, Devereux Theodora R, Sills Robert C
Abstract excerpt
Treatment with 8-methoxypsoralen (8-MOP) and ultraviolet radiation (primarily UVA), called PUVA therapy, has been used to treat different chronic skin diseases but led to a significant increased risk for skin cancer. The National Toxicology Program (NTP) performed a study in mice treated with PUVA that showed a significant increase in squamous cell carcinomas of the skin. In the present study, we evaluated the...
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