Article
An unexpected spectrum of p53 mutations from squamous cell carcinomas in psoriasis patients treated with PUVA.
Photochemistry and photobiology - 1 Aug 1997
Wang X M, McNiff J M, Klump V, Asgari M, Gasparro F P
Abstract excerpt
Photochemotherapy employing 8-methoxypsoralen and long-wavelength ultraviolet radiation (UVA, 320-400 nm) is widely used in the treatment of psoriasis. The photoactivation of psoralens in skin cells leads to formation of DNA photoadducts which may be responsible, at least in part, for the efficacy of these photochemotherapies. However, mutations arising from these adducts may also lead to the well-characterized...
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