Article
p53 mutations in cutaneous lesions induced in the hairless mouse by a solar ultraviolet light simulator.
Molecular carcinogenesis - 1 Jul 1998
Queille S, Seite S, Tison S, Medaisko C, Drougard C, Fourtanier A, Sarasin A, Daya-Grosjean L
Abstract excerpt
We investigated skin lesions induced in hairless SKH:HR1 mice by chronic exposure to a solar ultraviolet light (UV) simulator for alterations of the p53 gene in conserved domains. Mutations of exons 5-8 of the p53 gene in skin lesions were screened in 31 benign skin lesions (hyperplasias), 25 pre...
Topics
- Animals
- Female
- Genes, p53
- Mice
- Mutation
- Neoplasms, Radiation-Induced
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Precancerous Conditions
- Skin Neoplasms
- Sunlight
- Ultraviolet Rays