Article
p53 mutation in squamous cell carcinomas from psoriasis patients treated with psoralen + UVA (PUVA).
The Journal of investigative dermatology - 1 Aug 1997
Nataraj A J, Wolf P, Cerroni L, Ananthaswamy H N
Abstract excerpt
Individuals suffering from psoriasis are treated with a combination of psoralen and UVA radiation, commonly referred to as "PUVA" therapy. Epidemiologic studies have shown that PUVA therapy is a risk factor for skin cancer in psoriasis patients. Although PUVA treatment induces skin cancer in laboratory animals, it is unknown whether the increased incidence of skin cancer reported in PUVA-treated psoriasis...
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