Article
A polymorphic 3'UTR element in ATP1B1 regulates alternative polyadenylation and is associated with blood pressure.
PloS one - 1 Jan 2013
Prasad Megana K, Bhalla Kavita, Pan Zhen Hua, O'Connell Jeffrey R, Weder Alan B, Chakravarti Aravinda, Tian Bin, Chang Yen-Pei C
Abstract excerpt
Although variants in many genes have previously been shown to be associated with blood pressure (BP) levels, the molecular mechanism underlying these associations are mostly unknown. We identified a multi-allelic T-rich sequence (TRS) in the 3'UTR of ATP1B1 that varies in length and sequence composition (T22-27 and T12GT 3GT6). The 3'UTR of ATP1B1 contains 2 functional polyadenylation signals and the TRS is...
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