Article
APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts.
PloS one - 1 Jan 2015
Niavarani Ahmadreza, Currie Erin, Reyal Yasmin, Anjos-Afonso Fernando, Horswell Stuart, Griessinger Emmanuel, Luis Sardina Jose, Bonnet Dominique
Abstract excerpt
Classic deamination mRNA changes, including cytidine to uridine (C-to-U) and adenosine to inosine (A-to-I), are important exceptions to the central dogma and lead to significant alterations in gene transcripts and products. Although there are a few reports of non-classic mRNA alterations, as yet there is no molecular explanation for these alternative changes. Wilms Tumor 1 (WT1) mutations and variants are...
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